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ESR involves the enzymatic degradation of collagen-rich fibrous septae which play a key role in the pathophysiology of cellulite

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and the inhibition of enzymes involved in NAD + degradation, such as PARPs and CD38

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The interactions between the Fc region of the therapeutic IgG and FcRs on surrounding effector cells are particularly relevant in the MM environment

That is why its effect in studies extends far beyond the gastrointestinal tract, where it was originally discovered