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It was illustrated that intraperitoneal administration of the tetrapeptide SS-31 to Tg2576 mice (AD model) in the cerebral cortex reduces the level of the A peptide and increases the level of mRNA and the synthesis of mitochondrial dynamic proteins (Mfn1/Mfn2), mitochondrial biogenesis (PGC1- and Nrf2), and synaptic functions (synaptophysin and PSD95) [51]