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Description
Heteroplasmic mtDNA mutation (T-G) at 8993 can cause Leigh disease when the percentage of abnormal mtDNA is high

The modest efficacy observed in human studies, such as in the case of oxytocin, likely reflects the significant heterogeneity of autism, differences in developmental trajectories, and the limited validity of existing preclinical models [136]
Jan 2012;33(1):199.e1-12

Sinha, University of California, Los Angeles, United States Updates Copyright 2024 Skrobucha, Pindlowski, Krajewska, Grabowski and Jonik
Human applications, as well as preclinical data, which directly translate to clinical scenarios, received priority treatment in the selected literature

doi: 10.1073/pnas.0400093101
