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Where possible, avoid suddenly reducing the B 12 dose or injection frequency, as too rapid dose reduction may worsen symptoms or lead to symptom recurrence.26 Instead, gradually increase the interval between B 12 injections over the course of several months while monitoring symptoms

Alternatively, the insect is pre-fed on a calcium supplement

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Yes, though it is rare

Mechanistic studies to better understand the molecular targets and pathways involved in peptide action could help identify potential adverse effects and inform safer clinical use