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Malondialdehyde and 4-hydroxynonenal are two major end-products of lipid peroxidation and their elevated levels in CSF or blood have been shown to be correlated with the pathological severity of AD and PD (33,83)

Forcina et al

22,24,55 ), here, we carefully selected the NaOX doses for in vitro studies by treating primary hepatocytes and HepG2 cells with increasing concentrations of NaOX or with PA, which significantly downregulated AGXT and enhanced intracellular oxalate accumulation as found in MASH

PloS One (2014) 9(11):e113020

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However, this was based on comparison with liver or kidney, which are highly specialized detoxifying organs (36)