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This is true for severe deficiency or malabsorption issues

[DOI] [PMC free article] [PubMed] [Google Scholar] 97.Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, Birsoy K, et al

Consider supplementation when the patient has risk factors associated with B 12 Deficiency as described in see Table 1: Patient Risk Factors Associated with B 12 Deficiency above

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Oral neomycin, colchicine, aminosalicylic acid, H2 histamine receptor antagonists: may decrease the oral absorption of vitamin B12
