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However, intact BBB consisted of endothelial cells and tight junctions impedes the brain permeability of therapeutic agents, which largely comprises their therapeutic efficacy of CNS diseases

This is why its effects aren't just skin-deep

[DOI] [PMC free article] [PubMed] [Google Scholar] 722

Anyone who has experienced benzodiazepine withdrawal understands the severity of rebound anxiety and depression that can accompany discontinuation
reported that activation of the NLRP3 inflammasome, including increased mitochondrial superoxide production and lipid peroxidation, may persist after short-term patient recovery [80]
