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[28] Metal ion binding [edit] Beyond the iron-sulfur proteins, many other metal cofactors in enzymes are bound to the thiolate substituent of cysteinyl residues

Pharmacological inactivation of the PHD enzymes by 2-oxoglutarate analogues is sufficient to stabilize HIF-1, but it is nonspecific for individual PHD isoforms

Fer-1, a lipid-ROS scavenger and also a potent ferroptosis inhibitor [36], strongly protects against erastin-induced ferroptosis, and this protective effect is associated with a strong reduction in lipid-ROS accumulation and a partial reduction in cytosolic ROS accumulation

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