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Amino acids and mTOR mediate distinct metabolic checkpoints in mammalian G1 cell cycle

The presence of an extra X chromosome (Klinefelter syndrome) or an extra Y chromosome, the presence of two X but no Y chromosome in a male, and microdeletions or translocations affecting the X or Y chromosome are examples of chromosomal problems that can disrupt sperm production and overall genital and gonad development, resulting in azoospermia (absence of sperm) and infertility

doi: 10.1016/0006-291x(85)91687-0

A.RosenstockJ.KimT.BurnsC.SkareS.et al (2016)

These effects are particularly relevant for tendons and ligaments, which are inherently limited by poor vascular supply

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