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The addition of xylazine or other contaminants to fentanyl can make it more dangerous, as patients who overdose on these mixes are not as responsive to emergency opioid overdose treatments, such as naloxone (Narcan).(9) Opioid Use Disorder Symptoms Opioids produce feelings of euphoria that make it more likely that people will continue to use opioids, despite any negative consequences that may go along with opioid use