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USF1 transcriptionally activates USP14 to drive atherosclerosis by promoting EndMT through NLRC5/Smad2/3 axis

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E-cadherin binds to both WT and mutant -catenin, and -catenin is released from the cell membrane and degraded by loss of E-cadherin It is well-documented that E-cadherin sequesters -catenin to the cell membrane, and thereby inhibits EMT progression 18,19