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The multifaceted nature of PD comorbidities necessitates a precision medicine approach tailored to the patients full clinical context ( 4.1 Neuropsychiatric symptoms: depression, anxiety, and cognitive decline Over 4060% of PD patients experience depression and anxiety, which are often underdiagnosed and misattributed to motor disability ( Cognitive impairment, ranging from mild cognitive dysfunction to Parkinsons disease dementia (PDD), affects up to 80% of individuals in advanced stages (25)

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Some studies explored the gut-brain axis, dopamine activity, serotonin signaling, and neuroprotection

These may include, for example, impaired motor control, behavioral changes such as depression and language problems

Los estudios rusos publicados de biogerontologa han utilizado Epithalon en un rango amplio de 1,5 g a 100 g por dosis en modelos roedores envejecidos, tpicamente por va subcutnea en ciclos de 5-10 das repetidos 1-2 veces al ao

On the other hand, autophagy leads to a significant decrease in intracellular GSH levels and vice versa 67