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Today, we know that the polymorphism of the APOE gene, in particular the presence of the APOE4 allele, alters neuronal iron homeostasis leading to excessive intracellular iron deposition

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Alternatively, increased longevity from cold exposure may be due to a modulation of genes, such as TRPA-1 and DAF-16 [26]

Sinks et al
Following a low homocysteine diet without enough protein could backfire
