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Metabolic fingerprints (e.g., OCR/ECAR ratio, mtDNA copy number) are emerging as key indicators for assessing resistance risk [176, 177]alongside KRAS and BRAF mutation status

203 Despite this, advances in cancer mutation analysis and TCR sequencing have made it possible to assess whether an individual patient lacks the necessary TCRs to recognize crucial neoantigens

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Novinscak et al., 2008

no human RCTs have established efficacy

People who focus intently on the needle report more discomfort than those who minimize their attention to it