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In parallel, GHK-Cu peptide apparently suppressed p38 MAPK phosphorylation, which is a pathway activated by inflammatory and oxidative stimuli and linked to cytokine production

The mechanism involves positive regulation of the expression of ALDHs and cytoprotective enzymes (e.g

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Another mode by which GSH could potentially modulate neurotransmission is by its effects on redox-regulated presynaptic proteins such as synaptosomal-associated protein 25 (SNAP-25) and N-ethylmaleimide-sensitive factor (NSF)

2006 Jun 29;354(26):2764-72

For instance, induction of iNOS in microglia leads to a decrease in cellular GSH level, whereas, under comparable conditions, the GSH status of astrocytes remains largely unaffected ( - exposure (Makar et al., 1994)