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4 Delivery Systems for Cancer Vaccines Significant limitations, including low efficacy, side effects, poor tumor penetration, and increased toxicity, often hinder the effectiveness of immunotherapy and lung cancer vaccines (Lahiri et al., 2023)

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Scacheri et al., 2004), as well as addressing the issues of sequence-dependent and chemical-dependent toxicity ( in vitro and animal studies, there are no reports of such products being utilized in clinical trials thus far

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