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Okada K, Tanaka H, Temporin Ko, Okamoto M, Kuroda Y, Moritomo H, Murase T, Yoshikawa H (2010) Methylcobalamin increases Erk1/2 and Akt activities through the methylation cycle and promotes nerve regeneration in a rat sciatic nerve injury model

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This unique property means both local and systemic administration can support healing, though local injection near the injury typically produces faster results