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For providers, having a potent oral option improves long-term adherence for patients who are averse to subcutaneous injections

Likewise, it led to a marked downregulation of COX-2 and iNOS, which led to the suppression of NF-B

Targeted delivery systems, such as CRC-specific nanoparticles or ultrasound-responsive agents, could mitigate off-target effects

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it is considered to be likely multifactorial [72]