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Persistent epilepsy and seizures have the potential to result in neuronal damage (Lucke-Wold et al., 2015)

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This is true whether you opened it yesterday or three months ago: what matters is the date of the first puncture, not how much liquid is left

In contrast, asymptomatic TTR-V30M carriers did not differ significantly from healthy TTR wild-type controls, indicating that elevated PGA correlates with disease manifestation (Table 1)

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