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Following ELAVL1 inducible knockdown, we verified a 1.5-fold and 1.3-fold decrease in the luciferase signal when the reporter-KGA 3-UTR and reporter-GAC 3-UTR constructs were transfected into the cells (Fig

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Another important miRNA regulating cell metabolism is miR-378/378*, embedded within gene encoding peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1), a transcriptional regulator of oxidative energy metabolism

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and (v) the greatest FA alterations we saw upon LIPE inhibition (e.g., 18:1n9) were those most abundant in phospholipid membranes, thus having potentially the most impact on membrane dynamics