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A report showed that peroxidized lipids alter membrane fluidity in liposomes (Borst et al., Chemicals Used to Create PD Model To clarify the pathophysiological process of PD and to evaluate the efficiency of PD-targeted medicines, sophisticated models have been developed that use a panel of chemicals to reproduce and imitate the neurodegeneration process of PD

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Inhibition of Drp1 expression or reduction of Drp1 activity significantly reduces the number of mature autophagosomes and inhibits the formation of autophagic microsomes, and mitochondrial fragmentation and Parkin translocation are significantly suppressed