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Some people take B12 injections short-term to correct a deficiency, while others use them long-term for ongoing support, especially if they have: We recommend getting lab tests periodically to assess B12 levels and determine if continued supplementation is necessary

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A 2025 orthopaedic sports medicine systematic review describes increasing use despite lack of FDA approval and bans in sport, and emphasizes that the evidence base is dominated by preclinical studies with limited high-quality human data
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