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[PubMed Citation] Pregnant animal studies Reproductive and developmental toxicity studies performed in rats at oral doses up to 6.7 times the recommended human intravenous dose and in rabbits at doses up to 3.3 times the recommended human intravenous dose revealed no evidence of impaired fertility or embryofetal toxicity

Blood 123, 29973006

Influence of homocysteine on matrix metalloproteinase-2: Activation and activity

[DOI] [PubMed] [Google Scholar] 170.Perez R.S., Zuurmond W.W., Bezemer P.D., Kuik D.J., van Loenen A.C., de Lange J.J., Zuidhof A.J

Signs concentration may be too high Persistent irritation that doesn't resolve after two weeks of consistent use signals concentration exceeding your skin's tolerance

Concentration: Most cosmetic formulations contain 0.5% to 2% GHK-Cu