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Note, however, that the particular points (i.e., hepatic endothelial dysfunction or remodeling and constriction of the intrahepatic sinusoidal vasculature [119,120,121]) were not studied with BPC 157 therapy

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However, the study of ferroptosis is still in its infancy, and many problems remain unsolved 1 : P53 is an important regulator of apoptosis, and a large number of apoptotic factors are dependent on P53 activation to regulate the occurrence of apoptosis

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Icariin demonstrates a protective effect against gentamicin-induced ototoxicity in HEI-OC1 cells and cochlear explants through AMPK-SIRT3 signaling cascade activation, thereby offering a novel approach for addressing ototoxicity resulting from aminoglycoside antibiotics (Hu and Ma 2021)