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The inhibitory effects of roflumilast on lipopolysaccharide-induced nitric oxide production in RAW264

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The increase of serum HMGB1 appears to be a key lethal factor in sepsis, and the control of HMGB1 is crucial in the management of sepsis (56, 57)

2 Methods 2.1 Animal procedures The experiment utilized 10-week-old WKY rats (n = 20) as the control group (Norm group) and 10-week-old SHR (n = 20), sourced from Vital River Laboratory Animal Technology Co., Ltd

Although administration of some antioxidants may suppress neurodegeneration, no clinically apparent efficacy has been demonstrated yet