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The developing brain has high energy needs for basic cellular functions and for synthesis of neurotransmitters, nucleic acids, proteins, carbohydrates and lipids needed for cell growth and myelination [134]

Cell models: The enzymatic activity of CBS and the outcome of inhibition/downregulation of the enzyme, has been studied in fibroblasts of Down syndrome patients

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Confocal imaging An inverted LSM880 microscope was used with a Plan-Apochromat 63 1.4 [numerical aperture (NA)] oil objective with a working distance of 0.19 mm

The three primary curcuminoids in C

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