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Although the exact cause is still unknown, several factors are believed to contribute to its development

[6] [4] Haematological improvements typically begin with reticulocytosis (increased production of new red blood cells) within 35 days

Cancer Cell 20 , 524537 (2011)

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If ADE of neutralizing or non-neutralizing mAbs is a concern, the Fc portion of these antibodies could be engineered with mutations that abrogate FcR binding 80

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