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Park H, Choi K, Shin I

In addition, glutamine can be used as a precursor for proline synthesis, which is a key component of collagen and ECM formation [82]

Importantly, when combined with curcumin, 3,4-DHPV exhibited a strong synergistic anti-inflammatory effect at low micromolar concentrations (5 M 3,4-DHPV + 5 M curcumin), markedly reducing the expression of multiple pro-inflammatory genes (e.g., IL-6, MCP-1, COX-2, IL-1, TNF-, iNOS) and their secreted protein levels (Marcolin et al., 2025)

In particular, DHLA is able to regenerate other endogenous antioxidants (for example, vitamins E and C) [11] and neutralize free radicals

Short NJ, Jabbour EJ, RavandiF, Huang X, Jain N, Sasaki K, Pemmaraju N, Daver NG, Khoury JD, Jorgensen JL, Alvarado Y, Konopleva MY, Garcia-Manero G, Kadia TM, Yilmaz M, Borthakur G, MD, Burger JA, Kornblau SM , Wierda WG, DiNardo CD, Ferrajoli A, Nasnas P, Jacob J, Garris RE, O'Brien SM, Kantarjian HM

Regulation of mammalian O 2 homeostasis by hypoxia-inducible factor 1