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ATP7A continuously recycles between the trans -Golgi network (TGN) and the PM, whereas ATP7B traffics between the TGN and a cytosolic vesicular compartment

Siggins GR, Roberto M, Nie Z (2005)

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Psychiatry 7, 149156

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In metabolic disorders (e.g., type 2 diabetes and obesity), amylin deficiency exacerbates uncontrolled feeding and metabolic dysregulation [3], establishing it as a pivotal therapeutic target for obesity