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10.1002/1873-3468.13718 68 StockmanP
The WADA Prohibited List is an international standard updated annually to specify substances and methods banned under the World Anti-Doping Code
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Compared to mice with a global alcohol dehydrogenase 2 gene knockout ( Aldh2) , which exhibit remarkably higher blood acetaldehyde concentrations following acute oral alcohol administration than wild-type controls, mice with hepatocyte-specific Aldh2 deletion showed only about a 50% increase in systemic acetaldehyde (123)

Activated AKT phosphorylates the cytoplasmic phosphorylating rate-limiting enzyme phosphoenolpyruvate carboxy kinase 1, which is translocated to the ER and acts as a protein kinase that phosphorylates the INSIG protein and disrupts the interaction between the INSIG protein and the SREBP shear-activating proteins, which in turn activates the transcription of SREBPs as well as downstream genes related to lipid synthesis and uptake and promotes the progression of HCC (102)

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