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Concurrently, NAD + depletion, exacerbated by poly(ADP-ribose) polymerase-1 (PARP-1) hyperactivation, cripples sirtuin activity, impairing mitochondrial biogenesis via peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1) dysregulation and reducing antioxidant defense through Forkhead box O (FOXO) signaling

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OwenOEMorganAPKempHGSullivanJMHerreraMGCahillGFJr.Brain metabolism during fasting

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NPSI, Neuropathic Pain Symptom Inventory
