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L., Vines, D., Green, D., Waldron, J., Gullane, P., Bristow, R., & Liu, F.-F

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(2000), in Life Sciences , extended this work into matrix metalloproteinase (MMP) biology, finding that GHK-Cu exposure elevated MMP-2 expression in fibroblast cultures while simultaneously upregulating tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2).[6] The significance here is the pairing: GHK-Cu appears to promote a coordinated remodeling response controlled matrix breakdown balanced by inhibitory regulation rather than simply driving one-directional collagen accumulation

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