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Furthermore, conducting riskbenefit evaluations of omega-3 PUFA administration is crucial, aimed at identifying patient groups for whom omega-3 PUFA therapy would present an optimal riskbenefit balance (97)

The rate-limiting enzyme of de novo serine synthesis is 3-phosphoglycerate dehydrogenase (PHGDH), of which the copy number is reported to be significantly increased in melanoma to ensure tumor cell survival and proliferation under low physiological serine concentrations