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Costunolide inhibits pulmonary fibrosis via regulating NF-kB and TGF-beta1/Smad2/Nrf2-NOX4 signaling pathways

Indeed, we demonstrated that GSH finely compensates the decline of SOD1 activity in: (i) cells expressing less active SOD1 mutant found in familial amyotrophic lateral sclerosis (Ciriolo et al., 2001)

This dual role suggests that p53 may act as a promising therapeutic target in OA therapy, achieving the synergistic effect of eliminating lesioned cells while protecting normal tissues by precisely regulating the balance between apoptosis and ferroptosis in different cell populations

Key benefits include: Antioxidant Properties: Glutathione helps remove toxins and stressors, potentially preventing chronic diseases

126 DMF, dehydroabietic acid, and Ginkgo biloba B can ameliorate alcoholic hepatitis mainly through the activation of the Nrf2 pathway