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It is also possible that local hypoxia induced by exercise can contribute to muscle injury and inflammation by decoupling between energy production (ATP from the Krebs cycle) and energy consumption in the cells

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Coenzyme Q10 and Heart Failure: A State-of-the-Art Review

Although the role of these ROS currently remains unclear, iNOS activity is low in diabetic ulcers [90], and iron is deposited in the tissue of skin ulcers due to stasis dermatitis [91]

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