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Schizophr Bull 44(5):958965

As ongoing research sheds light on its potential, we could see a paradigm shift in how we approach aging, emphasizing not just longevity but enhanced quality of life

b Crosses the line of no effect

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At lower concentrations or shorter exposures, classical apoptotic pathways predominate, characterized by caspase activation, chromatin condensation, and cell shrinkage without inflammation (Tabuchi et al., 2011)

In the quest for novel metabolic targets, approaches such as CRISPRCas9-mediated synthetic lethality screens targeting metabolic genes offer a pathway for identifying specific metabolic targets of interest, particularly in vivo