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This model has been used to study the role of monoamine neurotransmitters in the development of FM and to evaluate potential treatments that target these neurotransmitters mainly by inhibiting the activity of vesicular monoamine transporter (VMAT) and increasing the oxidative stress in nerve cells 32,34,35

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Consistent with this, the results of immunohistochemistry (IHC) of 30 pairs of paraffin-embedded HCC and paired normal liver tissues showed that the expression of KCNN3 protein was upregulated and highly positively stained in a large percentage of HCC tissues compared with paired normal liver tissues (Fig

10.1016/j.molcel.2004.07.016 11 ChaikuadA.BullockA

doi: 10.1007/s12094-008-0171-3

Madry, C., Mesic, I., Bartholomaus, I., Nicke, A., Betz, H., and Laube, B., Biochem
