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Ethics declarations Acknowledgements The authors are grateful to the multidisciplinary team of dedicated nurses, dietitians, psychosocial workers and physicians at the Diabetes Center at Dana-Dwek Childrens Hospital, and to E

doi: 10.3322/caac.21398 31 RobsahmTEAagnesBHjartkerALangsethHBrayFILarsenIK

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Current peptides require frequent injections due to rapid degradation and poor oral bioavailability ( Second-generation peptides incorporating chemical modifications to enhance stability, selectivity, and potency are under development