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The overall appearance of density can increase even without dramatic new follicle activation, simply because existing follicles are producing healthier hair

Vitamin B 12 deficiency Vitamin B 12 deficiency , also known as cobalamin deficiency , is the medical condition in which the blood and tissues have a lower than normal level of vitamin B 12

By assigning metabolites to the signals shown in the loading plot (Figs 4B and S5B) and quantifying the variation observed for each metabolite among the different classes, we found that overall, vB12 treatment induced significant metabolic changes in Tbx1 +/ mice only (Figs 4A, S5A, and S6, Table S1, Group 3)

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LD density was defined as the mean grayscale intensity (0 = black, 255 = white) within the boundary of each LD, and the analysis was performed by an investigator blinded to the experimental conditions