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Farook MR, Croxford Z, Morgan S, Horlock AD, Holt AK, Rees A, et al

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The allometric approach is a less complicated empirical approach developed based on the cross species similarities in biology, physiology, and anatomy utilizing a power function correlating physiological parameters with body size.19 The allometric projections have been demonstrated to work well for small molecules, especially those that primarily undergo renal elimination.14 However, when small molecule drugs display high crossspecies variability in PKs (e.g., due to metabolism), this method may not work well

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10.1016/j.actbio.2022.03.036 114 LiL.WanJ.WenX.GuoQ.JiangH.WangJ.et al (2021a)