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Our data revealed that HuR has the most decisive impact on the KGA/GAC protein level on a cell background that is glutamine withdraw and glutaminase-inhibition resistant (which even includes some TN tumor cells), implying that it is not the HuR levels by itself, but glutamine-dependent TCA cycle itself is the critical factor behind HuR having the most pronounced effect over KGA/GAC levels

10.1158/1078-0432.CCR-18-3223 59 GrewerC.GrabschE

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La endotoxina, tambin denominada lipopolisacrido (LPS), es un componente de la membrana de microorganismos gramnegativos, los cuales representan el 70% de los microorganismos residentes del lumen intestinal, correspondientes a aproximadamente 500-1000 especies bacterianas distintas

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doi: 10.3389/fphar.2025.1591825 Received 11 March 2025 Accepted 28 August 2025 Published 08 October 2025 Volume 16 - 2025 Edited by Er Sheng Gong, Gannan Medical University, China Reviewed by Guillermo Federico Spitzmaul, National Scientific and Technical Research Council (CONICET), Argentina Leonardo Dionisio, National Scientific and Technical Research Council (CONICET), Argentina Updates Copyright 2025 Giannini, Soldi, Elli, Sagheddu, Castagnetti, Viciani, Salvini, Battistuzzi, Milazzo, Alibrandi and Sidoti