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Ermiao San attenuating rheumatoid arthritis via PI3K/AKT/mTOR signaling activate HIF-1 induced glycolysis

PLoS ONE 5, e11552 (2010)
Anything that boosts estrogens (artificial sources that can come from birth control pills, non-bio-identical hormone replacement, or pregnancy) or estrogen dominance can increase the amount of the protein that binds T4

Conclusion: Grx2s anti-apoptotic and cytoprotective roles may make it a potential drug target to treat oxidative stress-induced diseases Despite being overlooked, research throughout the years has portrayed Grx2 as a capable and robust antioxidant enzyme through direct detoxification of free radicals, cytoprotection, and anti-apoptotic abilities [5, 23]

The underlying pharmacological rationale for this specific tripartite combination relies on targeting multiple physiological bottlenecks simultaneously, thereby preventing the biological healing process from stalling at any single point of failure

It's not exactly clear how MSM works, though
