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Description

Natural hydrogels are designed based on natural biomaterials such as decellularized extracellular matrix (dECM), collagen, silk fibroin, hyaluronic acid (HA), elastin, and others, which can offer advantages such as biomimetics, biodegradability, biocompatibility and non-toxicity, hydrophilicity, flexibility, availability, and cost-effectiveness

Metabolites such as indoxyl sulfate and pcresol sulfate, when BBB integrity is compromised, can interacted with glial cells to promote oxidative stress, proinflammatory cascades, and mitochondrial dysfunction within the CNS

Feyzi-Dehkhargani et al., 2012

Flow cytometry quantification further confirmed that the fluorescence intensity in Se/LDH@PEG-M-treated groups decreased by 79.9% compared to LPS controls (Fig