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Subcutaneous administration appears most common in published protocols, though intramuscular, intraperitoneal (in animal models), and even oral routes have demonstrated efficacy

Exposing sermorelin to room temperature for extended periods or, conversely, freezing it can cause it to break down and lose its effectiveness

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Hence, there is evidence for the hypothesis that pathophysiological mechanisms underlying olfactory dysfunction are directly caused by a lack of orexin-A [126]