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Changes in plasma dopamine are partially determined by sympathetic nerve activity, as increased peripheral dopamine is associated with increases in sympathetic activity, and patients with a loss of sympathetic nerve function have low plasma dopamine concentrations (Goldstein and Holmes, 2008)

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Isothermal titration calorimetry The binding assays were performed using a MicroCal iTC 200 isothermal titration calorimeter (GE Healthcare)

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While cysteine readily autoxidises to cystine in the extracellular fluid, it is rapidly reduced to cysteine upon entering the cell

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