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[7] Babizhayev and colleagues published a further human clinical trial in 2009

Mechanistically, lactate accumulation, driven by PKM2, enhances Twist1-K150la, which in turn facilitates Twist1 phosphorylation, nuclear translocation, and regulation of TGFB1 transcription, thereby inducing an EndoMT-associated fibrotic phenotype in ischemic flaps
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Regulation of Hepatic Ketogenesis Nutritional Regulation Hepatic ketogenesis is regulated by nutritional and physiological cues (Kolb et al., 2021