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Description
High dietary fat consumption impairs axonal mitochondrial function in vivo

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Crit Rev Biochem Mol Biol 48:119

Renal carnitine loss may also affect the morphology and function of red blood cells and reduce the oxygen carrying and releasing capacity of red blood cells, thereby reducing tissue oxygen supply (including the kidney), and tissue hypoxia activates hypoxia-inducible factor 1 (HIF-1), which in turn reduces OCTN2 expression through the HIF-1-PPAR signaling pathway

The trials were held at least three days apart from each other to allow for adequate recovery time