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The combination of nivolumab and ipilimumab has been subsequently evaluated in non-cutaneous melanoma including acral, mucosal, and uveal melanoma, and the combination regimen shows sustained and improved response compared with either single agent, although with elevated toxicity but manageable safety profile

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(2007), increased oxidative stress (Whaley-Connell et al., 2011), and elevated blood glucose (Grundy et al., 2004) and cortisol (Rosmond, 2005)

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PMID: 39265666