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Enzyme-catalyzed activation of anticancer prodrugs

While the engraftment rates were similar between cohorts, the leukemia burden was significantly reduced in mice transplanted with MOLM-13 ABCC1 -knockout cells upon AZD-4320 treatment compared to vehicle treatment and to MOLM-13 AAVS1.1 control cells (Fig

10.1086/656524 J

P., Kema, I

Tsujihata M

[DOI] [PMC free article] [PubMed] [Google Scholar] 93.Nomura J., Busso N., Ives A., Matsui C., Tsujimoto S., Shirakura T., Tamura M., Kobayashi T., So A., Yamanaka Y
