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For instance, oral supplements may cause gastrointestinal issues, while IV therapy may lead to more immediate reactions, such as flushing or dizziness

Specifically, the Akt signal pathway directly acts on FoxO3a to reduce its expression, further inhibiting production of autophagy marker LC3B on the collagen matrix, leading to excessive collagen accumulation (Im et al., 2015)

Understanding its function and origins is essential to grasp how it influences aging

This occurs because the hyperactivation of the HPA axis, and consequently the glucocorticoid signaling system, may alter the epigenetic landscape and influence genomic regulation and function conducting to the development of aging-related diseases [41]